CAS 352000-07-8: 4H-1-Benzopyran-4-one, 5,6,7-trihydroxy-2-phenyl-, hydrate (1:1)

Baicalein is a flavonoid found in many plants, such as the roots of Scutellaria baicalensis. It has been shown to have anti-inflammatory and antioxidant properties. Baicalein has been shown to inhibit the production of inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α. Baicalein also inhibits the production of reactive oxygen species (ROS) and lipid peroxidation in vitro. This results in reduced inflammation and oxidative stress in vivo. Baicalein can be used as a cosmetically active ingredient for treating skin infections or wounds. It is also an influential strategy for enhancing collagen synthesis by activating extracellular signal regulated kinase 1/2 (ERK1/2).

Applications An inhibitor of 12-lipoxygenase, leukotriene biosynthesis and release of lysosomal enzymes. It also inhibits cellular Ca2+ uptake and mobilization and adjuvant-induced arthritis. Baicalein is the flavonoid component of Nepalese and Sino-Japanese crude drugs. References Nadler, J.L., et al.: J. Clin. Invest., 80, 1763 (1987), Ono, K., et al.: Biochem. Biophys. Res. Commun., 160, 982 (1989), Abe, K., et al.: Chem. Pharm. Bull., 38, 209 (1990)

Baicalein monohydrate blocks 12-lipoxygenase, curbs leukotrienes, lysosomal enzymes, Ca2+ dynamics, and fights arthritis.