CAS 352017-71-1: H-ALA-TYR-PRO-GLY-LYS-PHE-NH2

The peptide AYPGKF-amide based on the proteolytically-revealed tethered ligand sequence of the murine proteinase-activated receptor-4 (PAR-4) was shown to cause platelet aggregation with an EC₅₀ value of about 15 µM.

PAR-4 Agonist Peptide, amide (AY-NH2) is an agonist of proteinase-activated receptor-4 (PAR-4).

PAR-4 Agonist Peptide, amide

H-Ala-Tyr-Pro-Gly-Lys-Phe-NH2 is a selective inhibitor of aminopeptidase N. It has been shown to inhibit neutrophil and leukocyte recruitment in rat peritonitis models, as well as to reduce the severity of carrageenan induced paw edema in rats. H-Ala-Tyr-Pro-Gly-Lys-Phe NH2 also inhibits the activation of platelets by aspirin and reduces their aggregation, which may be due to inhibition of PAR4. PAR4 is a G protein coupled receptor that is activated by proteases such as thrombin and trypsin. Activation of PAR4 induces proinflammatory cytokines, leading to increased leukocyte recruitment and inflammation.

Peptide AYPGKF-NH2 is a Research Peptide with significant interest within the field academic and medical research. This peptide is available for purchase at Cymit Quimica in multiple sizes and with a specification of your choice. Recent citations using AYPGKF-NH2 include the following: Protease-activated receptor 4 activation increases the expression of calcitonin gene-related peptide mRNA and protein in dorsal root ganglion neurons Z Wang, D Chen, Z Zhang, R Zhang - Journal of , 2013 - Wiley Online Libraryhttps://onlinelibrary.wiley.com/doi/abs/10.1002/jnr.23280 Development of novel inhibitors of thrombosis for the prevention of cardiovascular events S Wilson - 2021 - era.ed.ac.ukhttps://era.ed.ac.uk/handle/1842/38363 PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets RA Henriksen, VK Hanks - Arteriosclerosis, thrombosis, and , 2002 - Am Heart Assochttps://www.ahajournals.org/doi/abs/10.1161/01.ATV.0000014742.56572.25 Protease-activated receptor 4: a critical participator in inflammatory response Q Fu, J Cheng, Y Gao, Y Zhang, X Chen, J Xie - Inflammation, 2015 - Springerhttps://link.springer.com/article/10.1007/s10753-014-9999-6 Molecular Mechanisms Regulating the Platelet Thrombin Receptor PAR4 PE Thibeault - 2020 - search.proquest.comhttps://search.proquest.com/openview/917facff59ec416fb10dada33ba87e1c/1?pq-origsite=gscholar&cbl=18750&diss=y Insights into Proteinase Activated Receptor 4 (PAR4) signaling, trafficking and biased agonism P Thibeault, JC Lesarge, M Fernandes - for Annual Meeting of , 2018 - jstage.jst.go.jphttps://www.jstage.jst.go.jp/article/jpssuppl/WCP2018/0/WCP2018_OR10-2/_article/-char/ja/ Characterization of thrombin-induced leukocyte rolling and adherence: a potential proinflammatory role for proteinase-activated receptor-4 N Vergnolle , CK Derian, MR D'Andrea - The Journal of , 2002 - journals.aai.orghttps://journals.aai.org/jimmunol/article/169/3/1467/34921 Proteinase-activated receptor-1 (PAR-1) activation contracts the isolated human renal artery in vitro M Tognetto, MR D'Andrea, M Trevisani - British journal of , 2003 - Wiley Online Libraryhttps://bpspubs.onlinelibrary.wiley.com/doi/abs/10.1038/sj.bjp.0705215 Activation of proteinase-activated receptors induces itch-associated response through histamine-dependent and-independent pathways in mice K Tsujii, T Andoh , JB Lee, Y Kuraishi - Journal of pharmacological sciences, 2008 - Elsevierhttps://www.sciencedirect.com/science/article/pii/S1347861319313477 Biological activity of Helicobacter pylori components in mammalian cells: is it independent of proteinase-activated receptors F Sekiguchi , Y Matsumoto, Y Maeda - J Physiol , 2012 - jpp.krakow.plhttps://www.jpp.krakow.pl/journal/archive/12_12/pdf/571_12_12_article.pdf Protease-activated receptors (PARs) as therapeutic targets: development of agonists/antagonists and modulation of gastrointestinal functions F Sekiguchi , A Kawabata - Drug Design Reviews-Online , 2004 - ingentaconnect.comhttps://www.ingentaconnect.com/content/ben/ddro/2004/00000001/00000004/art00002 P. Faria-Pinto, MTP Lopes & Andre Klein A Barra, KM Freitas, DG Marconato - researchgate.nethttps://www.researchgate.net/profile/Andre-Klein-7/publication/345507782_Naunyn-Schmiedeberg's_Archives_of_Pharmacology_Protease-activated_receptor_4_plays_a_role_in_lipopolysaccharide-induced_inflammatory_mechanisms_in_murine_macrophages_Protease-activated_receptor_4_play/links/5fa85422a6fdcc0624200b34/Naunyn-Schmiedebergs-Archives-of-Pharmacology-Protease-activated-receptor-4-plays-a-role-in-lipopolysaccharide-induced-inflammatory-mechanisms-in-murine-macrophages-Protease-activated-receptor-4-plays.pdf

Custom research peptide; min purity 95%. For different specs please use the Peptide Quote Tool