CAS: 354583-69-0

Azelaoyl PAF is a potent PPAR? (Peroxisome proliferator- activated receptor gamma) agonist which competes for the thiazolidinedione binding site. Azelaoyl PAF was isolated as one of a number of low MW species in oxidized low-density lipoprotein (oxLDL) which promoted the differentiation of monocytes. PPAR-gamma agonists like Azelaoyl PAF could play a role in the treatment of neurodegenerative disease Friedreich's ataxia.

Azelaoyl PAF is a potent PPARγ agonist that competitively binds thiazolidinediones.promotes the uptake of oxLDL by macrophages by upregulating CD36 expression.