CAS 355841-11-1: Desbutyllumefantrine
Formula:C26H24Cl3NO
InChI:InChI=1/C26H24Cl3NO/c1-2-3-10-30-15-25(31)24-14-19(29)13-23-21(11-16-4-6-17(27)7-5-16)22-12-18(28)8-9-20(22)26(23)24/h4-9,11-14,25,30-31H,2-3,10,15H2,1H3/b21-11-
InChI key:InChIKey=YLBUTQNEBVPTES-NHDPSOOVNA-N
SMILES:C(CNCCCC)(O)C1=C2C(/C(=C\C3=CC=C(Cl)C=C3)/C=4C2=CC=C(Cl)C4)=CC(Cl)=C1
Synonyms:- (9Z)-α-[(Butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-9H-fluorene-4-methanol
- Desbutyl-benflumetol
- Desbutyllumefantrine
- 9H-Fluorene-4-methanol, α-[(butylamino)methyl]-2,7-dichloro-9-[(4-chlorophenyl)methylene]-, (9Z)-
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Found 7 products.
(Z)-Desbutyl lumefantrine
CAS:(Z)-Desbutyl lumefantrine (DBL) is a drug used for the treatment and prevention of malaria. The drug is a prodrug that is converted to lumefantrine in vivo. DBL has significant interactions with other drugs, such as trifluoroacetic acid, which may lead to toxic effects or therapeutic failure. DBL should not be taken by nonpregnant women or women who are pregnant, as it can cause birth defects in the fetus. Pharmacokinetics of DBL were studied in healthy adult subjects and found to have linear pharmacokinetic properties in the concentration-time curve. It had a mean elimination half-life of 5 hours, an oral bioavailability of 98%, and low systemic clearance (0.2 L/h).Formula:C26H24Cl3NOPurity:Min. 95%Color and Shape:PowderMolecular weight:472.8 g/molDesbutyl Lumefantrine
CAS:Desbutyl Lumefantrine is a metabolite of lumefantrine with antimalarial activity.Formula:C26H24Cl3NOPurity:98%Color and Shape:SolidMolecular weight:472.83(Z)-Desbutyl Lumefantrine
CAS:Controlled ProductStability Light Sensitive Applications (Z)-Desbutyl Lumefantrine is a metabolite of Lumefantrine (L474000). References Lefevre, G., et al.: Br. J. Clin. Pharmacol., 54, 485 (2002); Schepers, U., et al.: J. Pharm. Biomed. Anal., 310 (2005)Formula:C26H24Cl3NOColor and Shape:NeatMolecular weight:472.83Desbutyl Lumefantrine-d9
CAS:Formula:C26H15D9Cl3NOColor and Shape:Yellow SolidMolecular weight:481.89Desbutyl Lumefantrine
CAS:Formula:C26H24Cl3NOColor and Shape:Pale Yellow SolidMolecular weight:472.85Desbutyl Lumefantrine HCl
CAS:Formula:C26H24Cl3NO·HClColor and Shape:Yellow SolidMolecular weight:472.83 36.46
