CAS 35620-71-4: 2-Phenoxynicotinic acid

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-Phenoxynicotinic acid is a drug that inhibits the activity of nitric oxide synthase, an enzyme involved in the production of nitric oxide. Nitric oxide is a gas that is produced by macrophages and other cells in response to inflammation or injury. It has been shown that 2-Phenoxynicotinic acid inhibits the production of nitric oxide in vitro. This drug has been used clinically to treat cardiovascular disorders and diseases, including arrhythmias, hypertension, angina pectoris, and coronary artery disease. 2-Phenoxynicotinic acid has also been shown to be effective against leishmania parasites. It binds to glutathione s-transferase, an enzyme that is found on the surface of cells and plays an important role in cellular detoxification processes. The binding of 2-Phenoxynicotinic acid with glutathione s-transferase leads to inhibition of this enzyme's enzym