CAS: 356783-10-3

Applications 6-​Fluoro-​3,​4-​dihydro-​4-​[5-​O-​[hydroxy[[hydroxy(ph​osphonooxy)​phosphinyl]​oxy]​phosphinyl]​-​β-​D-​ribofuranosyl]​-​3-​oxo-​pyrazinecarboxamide Sodium Salt was used in the preparation of novel pyrazine derivatives as antiviral agents. It is a salt analog of T-705RTP (T003210). References Egawa, H., et al.: PCT Int. Appl. (2001), WO 2001060834 A1 20010823; Egawa, H., et al.: Jpn. Kokai Tokkyo Koho (2004), JP 2004043371 A 20040212

Applications T-705RTP-13C5 Sodium Salt is a labeled salt derivative of T-705 (F103350) which has activity against the lethal H5N1 influenza A viruses. References Yousuke, F., et al.: Antimicrob Agent Chemother., 49, 981 (2005); Kiso, M., et al.: Proc. Natl. Acad. Sci. U.S.A., 107, 882 (2010)

T-705RTP sodium is a novel, modified diphosphate nucleotide that activates the formation of DNA and RNA. It is used as an antiviral and anticancer agent. T-705RTP sodium has been shown to be more potent than adenosine in inhibiting viral replication and has cytotoxic effects on cancer cells. The chemical formula for T-705RTP sodium is C6H14N5O7P.

T-705RTP sodium inhibits influenza virus RNA polymerase (IC50: 0.14 μM, Ki: 1.52 μM), displaying strong antiviral effects.