CAS: 358721-70-7

UBCS039 is the first synthetic Sirt6 activator(EC50 : 38 μM)

UBCS039

UBCS039 is a synthetic compound that modulates the activity of sirtuins, which are enzymes involved in cancer cell viability. It interacts with acetylated lysine residues and inhibits the activity of caspases, which are proteins involved in apoptosis. UBCS039 has been shown to inhibit the proliferation of human cancer cells by inducing autophagy, a process that is linked to carcinogenesis. This agent also has anti-inflammatory properties, which may be due to its inhibition of NF-κB activation and inhibition of COX2 expression.