CAS 35905-85-2: 3-Pyridinecarboxylic acid, 2-bromo-

2-Bromonicotinic acid

2-Bromonicotinic acid (2BA) is a bioactive molecule that can be used as a predictive model for the mechanism of action of δ opioid receptor agonists. 2BA binds to the δ opioid receptor and activates it by increasing chloride ion flow across nerve cell membranes. This increases the permeability of cells, which leads to an influx of water molecules into the cell. In addition, 2BA causes an increase in amine production, which then reacts with chloride ions to produce hydrogen peroxide and free radicals. These free radicals can cause damage to DNA and proteins within the cell, leading to cancer or other diseases. 2BA is also very reactive and can react with butyllithium, hydrochloric acid, or water molecules to form bromide ions. The bromide ions are then able to bind with amines to form small molecules called bromamines. Bromamines are able to pass through the blood brain barrier more easily than 2BA because

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.