CAS: 35959-05-8

3-Hydroxy-11-ursen-28,13-olide is a pentacyclic triterpenoid lactone, which is isolated from various plant sources, predominantly belonging to the family Lamiaceae. This compound acts primarily through modulation of inflammatory pathways, whereby it inhibits key enzymes and signaling molecules involved in inflammatory responses, such as cyclooxygenase and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). Additionally, it has been noted for inducing apoptosis in cancer cells by activating caspases and inhibiting survival pathways. The uses and applications of 3-Hydroxy-11-ursen-28,13-olide are largely concentrated in the realm of medicinal research. It is being extensively studied for its potential therapeutic effects against chronic inflammatory diseases and various types of cancers, including liver and breast cancer. Researchers are particularly interested in its role as a lead compound for the development of novel anti-inflammatory and anticancer drugs. Moreover, its natural origin opens pathways for developing complementary therapies in traditional medicine systems and enhancing the efficacy of existing therapeutic strategies. The compound’s specificity and effectiveness continue to be subjects of ongoing scientific investigations.

3β-Hydroxy-urs-11-en-28,13β-olide: strong liver cell protection; beats silymarin vs. CCl4 damage; weakly fights ovarian cancer cells.