CAS 36062-05-2: Hexahydrocurcumin

Hexahydrocurcumin

Applications Hexahydrocurcumin is a reagent in the synthesis of Gingerenone A (G387500) which is an antifungal and antiparasitic diarylheptenone that is isolated from Zingiber officinale (more commonly known as ginger), a medicinal plant that is used to treat inflammation and musculoskeletal disorders. References Ali, B., et al.: Food Chem. Toxicol., 46, 409 (2008); Bordia, A., et al.: Prost. Leuk. Ess. Fat. Acids, 56, 379 (1997); Choi, W., et al.: J. Appl. Biomed., 11, 15 (2013); Riaz, T., et al.: Nat. Prod. Res., 24, 1131 (2010); Srivastava, K. & Mustava, T.: Med. Hypoth., 39, 342 (1992)

Ketone phenol

Hexahydrocurcumin is a hydrogenated derivative of curcumin, which is a natural compound derived from the rhizome of the turmeric plant (Curcuma longa). This derivative is obtained through the catalytic hydrogenation of curcumin, resulting in enhanced chemical stability and bioavailability compared to the parent compound. Hexahydrocurcumin works by effectively scavenging free radicals and exhibiting robust antioxidant properties, which are superior to those of curcumin itself. This enhancement is attributed to the saturation of the double bonds in the structure, which reduces its susceptibility to degradation. Hexahydrocurcumin is primarily used in the fields of biomedical research and pharmacology. Its potent antioxidant activity makes it a subject of interest for studies related to oxidative stress, cellular protection, and anti-inflammatory responses. Additionally, due to its improved stability over curcumin, hexahydrocurcumin is being explored in applications involving therapeutic interventions for conditions such as cancer, neurodegenerative diseases, and metabolic disorders. Recent research suggests its potential utility in formulations where prolonged antioxidant activity is desirable, offering a promising avenue for future development in nutraceuticals and pharmaceuticals.

Applications Hexahydrocurcumin-d6 is an isotope labelled degradation product of Curcumin (C838500), a dietary anti-inflammatory and chemopreventive agent consisting of two methoxyphenol rings connected by a conjugated heptadienedione chain. References Gordon, D.N., et al.: J. Biol. Chem., 290, 4817 (2015);

Hexahydrocurcumin is a selective, orally active COX-2 inhibitor and inactive against COX-1.