4-(Methanesulfonylamino)benzonitrile, with the CAS number 36268-67-4, is an organic compound characterized by the presence of a benzonitrile moiety substituted with a methanesulfonylamino group. This compound typically appears as a solid at room temperature and is soluble in polar organic solvents. The methanesulfonylamino group contributes to its potential as a versatile building block in organic synthesis, particularly in the development of pharmaceuticals and agrochemicals. The presence of the nitrile functional group indicates that it may exhibit reactivity typical of nitriles, such as nucleophilic addition. Additionally, the sulfonamide functionality can influence the compound's biological activity and solubility properties. Its structural features suggest potential applications in medicinal chemistry, where it may serve as a lead compound for further modifications aimed at enhancing efficacy or reducing toxicity. As with many chemical substances, handling should be conducted with care, adhering to safety protocols to mitigate any risks associated with its use.

4-(Methanesulfonylamino)benzonitrile

36268-67-4: N-(4-cyanophenyl)methanesulfonamide

4-(METHANESULFONYLAMINO)BENZONITRILE

N-(4-cyanophenyl)methanesulfonamide

4-(Methanesulfonylamino)benzonitrile is a potent and selective vanilloid receptor antagonist. It has been shown to inhibit the uptake of nitro compounds by rat brain synaptosomes in vitro and to block the binding of [3H]nitro-N-methyl-4-phenylpyridinium ion (NMPA) to rat brain membranes. 4-(Methanesulfonylamino)benzonitrile has been shown to bind to albumin, which may be an important factor in its pharmacokinetics. This drug also binds with serum albumin, which may reduce its absorption after oral administration.

CAS 36268-67-4: 4-(Methanesulfonylamino)benzonitrile

4-(METHANESULFONYLAMINO)BENZONITRILE

Ref: IN-DA003K8T

N-(4-cyanophenyl)methanesulfonamide

Ref: 10-F351581

4-(Methanesulfonylamino)benzonitrile

Ref: 3D-LBA26867

4-(Methanesulfonylamino)benzonitrile

Ref: 54-OR470012