2,3,5-Trifluoroaniline is an aromatic amine characterized by the presence of three fluorine atoms attached to the benzene ring at the 2, 3, and 5 positions, along with an amino group (-NH2) at the 1-position. This compound is typically a colorless to pale yellow liquid or solid, depending on its purity and temperature. It is known for its relatively low solubility in water but is soluble in organic solvents such as ethanol and ether. The presence of fluorine atoms significantly influences its chemical properties, enhancing its reactivity and making it a useful intermediate in the synthesis of pharmaceuticals, agrochemicals, and other fluorinated compounds. 2,3,5-Trifluoroaniline exhibits moderate toxicity, and appropriate safety measures should be taken when handling it, as it can cause skin and eye irritation. Its chemical structure allows for various substitution reactions, making it a valuable building block in organic synthesis.

2,3,5-trifluoroaniline

2,3,5-Trifluoroaniline

2,3,5-Trifluoroaniline is an anhydrous gas that has been experimentally synthesized in the laboratory. It can be made by reacting 2-chloroaniline with hydrogen fluoride and chlorine. The synthesis of this compound requires high temperatures and a lot of energy. This reaction produces two isomers: 3-trifluoroaniline and 5-trifluoroaniline. Computational studies on these isomers show that the theoretical energies are not too different from experimental values. The electron affinity (EA) for 2,3,5-trifluoroaniline is -0.17 eV, which is higher than the EA for 2-fluoroaniline (-0.06 eV). The EA for 3-fluoroaniline (-0.08 eV) is lower than the EA for 2-fluoroaniline but still higher than that of 5-fluoroanil

CAS 363-80-4: 2,3,5-trifluoroaniline

2,3,5-Trifluoroaniline

Ref: 54-PC5403

2,3,5-Trifluoroaniline

Ref: 10-F001823

2,3,5-Trifluoroaniline

Ref: IN-DA003FFB

2,3,5-trifluoroaniline

Ref: 3D-FT104542