Des-Methyl TDF, also known as Tenofovir, is an antiretroviral medication primarily used in the treatment and prevention of HIV/AIDS and hepatitis B. It is a nucleotide reverse transcriptase inhibitor (NRTI) that works by interfering with the viral replication process. The chemical structure of Des-Methyl TDF features a phosphonate group, which is crucial for its activity, and it is often administered in its prodrug form, Tenofovir disoproxil fumarate (TDF), to enhance bioavailability. The substance is typically characterized by its solubility in water and its stability under physiological conditions, making it suitable for oral administration. Des-Methyl TDF is known for its efficacy in reducing viral load and improving immune function in patients. Common side effects may include gastrointestinal disturbances and renal toxicity, necessitating regular monitoring of kidney function during treatment. Overall, Des-Methyl TDF plays a significant role in modern antiviral therapy, contributing to improved health outcomes for individuals living with HIV.

Des-Methyl TDF

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Applications Desmethyl Tenofovir Disoproxil is a demethylated analogue and impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505).
References Yuan, L.-C. et al.: Pharm. Res., 18, 234 (2001);


CAS 365417-53-4: Des-Methyl TDF

Desmethyl Tenofovir Disoproxil Fumarate

Ref: TR-D294280

Desmethyl Tenofovir Disoproxil-d4 Fumarate

Ref: TR-D294282

Desmethyl Tenofovir Disoproxoil (Adefovir Disoproxil)

Ref: 4Z-T-0211

Desmethyl Tenofovir Disoproxoil

Ref: ST-EA-CP-T210003