CAS 3690-10-6: Zebularine
Formula:C9H12N2O5
InChI:InChI=1S/C9H12N2O5/c12-4-5-6(13)7(14)8(16-5)11-3-1-2-10-9(11)15/h1-3,5-8,12-14H,4H2/t5-,6-,7-,8-/m1/s1
InChI key:InChIKey=RPQZTTQVRYEKCR-WCTZXXKLSA-N
SMILES:O[C@H]1[C@@H](O[C@H](CO)[C@H]1O)N2C(=O)N=CC=C2
Synonyms:- 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-1,2-dihydropyrimidin-2-one
- 1-(β-<span class="text-smallcaps">D</span>-Ribofuranosyl)-2-pyrimidone
- 1-b-D-Ribofuranosyl-2(1H)-pyrimidinone
- 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2(1H)-pyrimidinone
- 1-β-<span class="text-smallcaps">D</span>-Ribofuranosyl-2-pyrimidinone
- 2(1H)-Pyrimidinone, 1-.beta.-D-ribofuranosyl-
- 2(1H)-Pyrimidinone, 1-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
- 4-Deoxyuridine
- NSC 309132
- Pyrimidin-2-one b-Ribofuranoside
- Pyrimidin-2-one β-<span class="text-smallcaps">D</span>-ribofuranoside
- See more synonyms
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Found 10 products.
Zebularine
CAS:Controlled ProductApplications It is a cytidine analogue, cytidine deaminase inhibitor, and DNA demethylating agent. References Driscoll, J., et al.: J. Med. Chem., 34, 3280 (1991), Ueki, T., et al.: Cancer Res., 60, 1835 (2000),Sherr, C., et al.: Cell, 116, 235 (2004), Dote, H., et al.: Clin. Cancer Res.,11, 4571 ( 2005),Formula:C9H12N2O5Color and Shape:NeatMolecular weight:228.204-Deoxyuridine
CAS:A cytidine analogue and inhibitor of DNA methyl transferases (DNMTs) with anti-cancer activity. This stable, hydrophilic compound forms covalent complexes between DNMT and zebularine-substrate DNA. It causes DNA lesions that block replication and cause replication fork collapse, leading to the formation of DNA double-strand breaks. It was also shown that zebularine-induced DNA methylation decrease in the IL-1β promoter region and disrupts molecular mechanisms of neuroinflammation. Moreover, this molecule down-regulates the DNA-methylation profile in the pluripotency genes’ promoters, which leads to improved development of somatic cell nuclear transfer (SCNT) embryos.Formula:C9H12N2O5Purity:Min. 95%Color and Shape:PowderMolecular weight:228.21 g/molZebularine
CAS:Formula:C9H12N2O5Purity:>98.0%(T)(HPLC)Color and Shape:White to Light yellow powder to crystalMolecular weight:228.20Zebularine
CAS:Zebularine (4-Deoxyuridine) is a DNA methylation inhibitor.Formula:C9H12N2O5Purity:100% - 99.84%Color and Shape:SolidMolecular weight:228.2
