CAS: 371775-74-5

N-Desmethyl Rosuvastatin-d3 Sodium Salt is a stable isotope-labeled compound, which is a synthetically produced standard. It serves as an internal standard in analytical chemistry, particularly in pharmacokinetic and metabolism studies. The compound incorporates deuterium atoms, denoted by "d3," which allows researchers to distinguish it from non-labeled equivalents through mass spectrometry techniques. This product acts by providing a reliable reference point for accurate quantification of the parent drug, Rosuvastatin, and its metabolites in biological samples. This is critical in elucidating the metabolic pathways and pharmacokinetics of Rosuvastatin, a commonly prescribed statin for lowering cholesterol. The use of N-Desmethyl Rosuvastatin-d3 Sodium Salt is essential in drug development and pharmaceutical research. It supports detailed studies on drug absorption, distribution, metabolism, and excretion (ADME), enabling scientists to better understand the drug's behavior in the body. Such insights facilitate the optimization of drug dosing regimens and enhance the safety and efficacy profiles of therapeutic agents.

Applications Inhibits the enzyme HMG-CoA reductase in vitro. References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),

Stability Hygroscopic Applications N-Desmethyl Rosuvastatin-d3 Sodium Salt is a labeled inhibitor of the enzyme HMG-CoA reductase in vitro. References Endo, A., et al.: J. Antibiot., 32, 852 (1979); Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990); Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977)

Applications Inhibits the enzyme HMG-CoA reductase in vitro. References Endo, A., et al.: J. Antibiot., 32, 852 (1979), Alberts, A.W., et al.: Drug Invest., 2 (Suppl. 2), 9 (1990), Kuroda, M., et al.: Biochim. Biophys. Acta, 486, 70 (1977),