CAS 383432-38-0: CP-724714

Inhibitor of ErbB2 (IC50 = 3 nM) and EGFR kinase (IC50 = 6.4 nM) with anti-proliferative effects. It inhibits ErbB2 receptor autophosphorylation and induces G1 cell cycle block. The CP 724714 treatment induces reduction of downstream ErbB2 receptor tyrosine kinase signalling, tumor cell apoptosis, release of caspase 3 and regression of tumors in in vivo and in vitro models.

CP-724714 (CP724714) is an effective and selective HER2/ErbB2 inhibitor (IC50: 10 nM), >640-fold selectivity against EGFR, Abl, InsR, PDGFR, IRG-1R, Src, VEGFR2

2-Methoxy-N-[(2E)-3-[4-[[3-Methyl-4-[(6-Methyl-3-Pyridyl)Oxy] Phenyl]Amino]-6-Quinazolinyl]-2-Propenyl-1-Yl]Acetamide

CP-724714