CAS 395-01-7: 2,2-Difluoroacetophenone

2,2-Difluoroacetophenone is a synthetic compound that has a trifluoromethyl group and a carbonyl group. It is stable in the presence of water vapor and hydroxyl groups. 2,2-difluoroacetophenone has been used to synthesize stable complexes with halides and other reagents. The use of this compound as an analog for phenol is being studied for its potential effects on insulin resistance and metabolic disorders. This chemical has also been tested for toxicity in rats, with no adverse effects found at low doses.

2,2-Difluoroacetophenone acts as an intermediate in the preparation of various substances such as pharmaceuticals. Further, it is used in the one-pot synthesis of difluoromethylated arenes from aryl chlorides and bromides. In addition to this, it undergoes reduction with (-)-diisopinocampheylchloroborane chloride to get R-alcohols of purity 85% ee.This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2,2-Difluoroacetophenone