2-Methyl-5-phenyl-1,3-oxazole is an organic compound characterized by its oxazole ring, which is a five-membered heterocyclic structure containing both nitrogen and oxygen atoms. This compound features a methyl group at the 2-position and a phenyl group at the 5-position of the oxazole ring, contributing to its unique chemical properties. It is typically a solid at room temperature and may exhibit moderate solubility in organic solvents. The presence of the phenyl group can enhance its stability and influence its reactivity, making it of interest in various chemical applications, including pharmaceuticals and materials science. The oxazole moiety is known for its potential biological activity, and derivatives of oxazole compounds are often investigated for their antimicrobial and anti-inflammatory properties. Additionally, 2-methyl-5-phenyl-1,3-oxazole may participate in various chemical reactions, such as electrophilic substitutions or cycloadditions, due to the electron-rich nature of the aromatic phenyl group. Overall, this compound represents a versatile structure in organic chemistry with potential applications in diverse fields.

2-methyl-5-phenyl-1,3-oxazole

3969-09-3: Oxazole, 2-Methyl-5-Phenyl-, 2-Methyl-5-phenyl-1,3-oxazole

2-Methyl-5-phenyloxazole is a reactive, phenacyl oxone that is used as an analogously to the oxadiazole. The oxadiazole is a heterocyclic compound with two nitrogen atoms and one oxygen atom. 2-Methyl-5-phenyloxazole reacts with primary alcohols in the presence of acetonitrile, carbon tetrachloride, or butyronitrile to form esters. This reaction can be carried out efficiently at room temperature without the need for a catalyst. The reaction proceeds through a nucleophilic substitution reaction in which the alcohol group on the reactant attacks the electrophilic double bond of 2-methyl-5-phenyloxazole. It also undergoes an intramolecular cyclization that forms benzonitrile from hydrochloric acid in trifluoromethanesulphonate.

CAS 3969-09-3: 2-methyl-5-phenyl-1,3-oxazole

2-Methyl-5-phenyloxazole

Ref: 3D-DAA96909

2-METHYL-5-PHENYLOXAZOLE

Ref: 10-F303259

5-Phenyl-2-methyloxazole

Ref: IN-DA00D043