CAS 398001-88-2: L-Cysteine,L-isoleucyl-L-valyl-L-leucyl-L-seryl-L-leucyl-L-a-aspartyl-L-valyl-L-prolyl-L-isoleucylglycyl-L-leucyl-L-leucyl-L-glutaminyl-L-isoleucyl-L-leucyl-L-leucyl-L-a-glutamyl-L-glutaminyl-L-alanyl-L-arginyl-L-alanyl-L-arginyl-L-alanyl-L-alanyl-L-argin

Urocortin II, a neuropeptide hormone within the corticotropin-releasing factor (CRF) family-which comprises mammalian CRF, urocortin I, urocortin III, frog sauvagine, and piscine urotensin I-displays 34, 43, and 37-40% sequence homology with rat and human CRF, human urocortin I, and human urocortin III, respectively. This compound enhances rabbit ventricular myocyte shortening and relaxation in both a time- and concentration-dependent manner. In vivo studies reveal that urocortin II lowers arterial blood pressure in both normotensive and spontaneously hypertensive rats through peripheral CRF2 receptor agonism, inducing dose-dependent tachycardia and hypotension at doses of 3 and 30 pmol/kg. Additionally, it mitigates the visceral pain response to colorectal distension at 10 and 20 μg/kg in conscious rats and delays gastric emptying in mice.

Ucn II (human), a new member of the CRF family of neuropeptides, binds selectively to the type 2 CRF receptor (CRF-R2), with no appreciable activity on CRF-R1.

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This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.