CAS 39967-60-7: 2,4(1H,3H)-Pyrimidinedione,5-(2-deoxy-b-D-erythro-pentofuranosyl)-

Deoxypseudouridine is a nucleotide analog.

2'-Deoxypseudouridine is a nucleotide that is synthesized from the sugar ribose-5-phosphate and uracil. It is used in biological systems to transfer phosphate groups, which are vital to the metabolism of energy. 2'-Deoxypseudouridine also binds to DNA, forming stable complexes with enzymes and other molecules. This nucleotide is often found in oligodeoxynucleotides, which are used as antiviral agents. 2'-Deoxypseudouridine has been shown to have antimicrobial activity against various viruses, including hepatitis B virus (HBV). It has also been tested for its ability to inhibit replication of HIV-1 in vitro. The enzyme glycosylase catalyzes the reaction of 2'-deoxypseudouridine with water, producing an unstable intermediate that spontaneously converts into dUMP and pyrophosphate.