CAS 40004-08-8: 1-(Ethoxycarbonylmethyl)piperazine

Applications N-(Ethoxycarbonylmethyl)piperazine is used in the preparation of aralkylpiperazine- and aryl-substituted hydrazines, particularly benzylpiperazineacetyl hydrazones of hydroxyaryl aldehydes, as selective inducers of apoptosis and activators of procaspases for use as anticancer agents. References Nakagawara, A., et al.: Cancer Res., 57, 4578 (1997), Denault, J., et al.: J. Biol. Chem., 278, 34042 (2003), Traven, A., et al.: Cancer Cell, 5, 107 (2004), Becattini, B., et al.: Chem. Biol., 11, 389 (2004),

Ethyl piperazin-1-ylacetate is a synthetic, anticancer compound that has significant cytotoxicity. It is an analogue of the immunosuppressant cyclosporine and inhibits the production of reactive oxygen species, leading to cell death by apoptosis. Ethyl piperazin-1-ylacetate has been shown to have a significant cytotoxic effect on human pancreatic cancer cells (PANC1) at low concentrations in vitro. This compound also showed antibacterial activity against Gram positive bacteria such as Staphylococcus aureus and Streptococcus pyogenes.

Ethyl (piperazin-1-yl)acetate