2-Chloro-6-(morpholin-4-yl)-5H-purine, with the CAS number 4010-81-5, is a purine derivative characterized by the presence of a chlorine atom at the 2-position and a morpholine group at the 6-position of the purine ring. This compound typically exhibits properties associated with purines, such as being a heterocyclic aromatic compound. It is often studied for its potential biological activity, particularly in the context of medicinal chemistry, where purine derivatives can act as nucleoside analogs or enzyme inhibitors. The morpholine moiety may enhance solubility and bioavailability, making it a candidate for pharmaceutical applications. The compound's structure suggests it may participate in hydrogen bonding and other interactions due to the presence of nitrogen atoms in both the purine and morpholine structures. Additionally, its chlorine substituent can influence its reactivity and interaction with biological targets. Overall, 2-chloro-6-(morpholin-4-yl)-5H-purine is of interest in drug development and research related to nucleic acid metabolism and related pathways.

2-chloro-6-(morpholin-4-yl)-5H-purine

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4-(2-Chloro-9H-purin-6-yl)morpholine (4CP) is a potent and selective inhibitor of the chk1 kinase. It has been shown to be cytotoxic in hek293 cells, but not in ht29 cells. 4CP inhibits the proliferation of cancer cells, and damages DNA by interacting with the phosphate backbone. The selectivity profile of 4CP is based on its inhibition of chk1 kinase activity. 4CP selectively inhibits chk1 kinases, while sparing other kinases such as p38 MAPKs, JNKs, ERKs, and PKC. This selective inhibition leads to cell cycle arrest at the G2/M phase transition point and apoptosis.

CAS 4010-81-5: 2-chloro-6-(morpholin-4-yl)-5H-purine

4-(2-Chloro-9H-purin-6-yl)morpholine

Ref: 3D-EAA01081

4-(2-Chloro-9H-purin-6-yl)morpholine

Ref: IN-DA00I7V9

2-chloro-6-(morpholin-4-yl)-7H-purine

Ref: 10-F634450