CAS 410528-02-8: Palovarotene
Formula:C27H30N2O2
InChI:InChI=1S/C27H30N2O2/c1-26(2)12-13-27(3,4)24-17-22(18-29-15-5-14-28-29)21(16-23(24)26)11-8-19-6-9-20(10-7-19)25(30)31/h5-11,14-17H,12-13,18H2,1-4H3,(H,30,31)/b11-8+
InChI key:InChIKey=YTFHCXIPDIHOIA-DHZHZOJOSA-N
SMILES:CC1(C)C=2C(=CC(/C=C/C3=CC=C(C(O)=O)C=C3)=C(CN4C=CC=N4)C2)C(C)(C)CC1
Synonyms:- 4-[(1E)-2-[5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]benzoic acid
- 4-{(1E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoicacid
- Benzoic acid, 4-[(1E)-2-[5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-2-naphthalenyl]ethenyl]-
- Clm 001
- Ipn 60120
- R 667
- Ro 3300074
- Sohonos
- Palovarotene
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Found 7 products.
Palovarotene-13C4
CAS:Controlled ProductFormula:C4C23H30N2O2Color and Shape:NeatMolecular weight:418.51Palovarotene
CAS:Palovarotene is a retinoid that is used in the treatment of bowel disease. It has been shown to bind to prostacyclin receptor and increase bone mass in the population. Palovarotene inhibits inflammatory bowel disease by inhibiting the production of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. Palovarotene also has been shown to inhibit the activation of osteogenic genes and suppress the growth of autoimmune diseases. This drug has a variety of analogs with different ester linkages that have different pharmaceutical dosages. The symptoms for overdose include nausea, vomiting, hair loss, skin rash, fever, joint pain, and fatigue.Formula:C27H30N2O2Purity:Min. 95%Molecular weight:414.54 g/molRef: 3D-FP167399
Discontinued productPalovarotene
CAS:Controlled ProductApplications Palovarotene, is a highly selective retinoic acid receptor gamma (RAR-γ) agonist that is under investigation as a potential treatment for emphysema. References Hind, M., et al.: Curr. Opinion Invest. Drugs, 10(11), 1243 (2009); Stolk, J., et al.: Therap. advances Respi. dise., 4, 319 (2010);Formula:C27H30N2O2Color and Shape:NeatMolecular weight:414.54palovarotene
CAS:Palovarotene (Ro 3300074) is an agonist of nuclear retinoic acid receptor γ (RAR-γ).Formula:C27H30N2O2Purity:96.89% - 98.05%Color and Shape:SolidMolecular weight:414.54
