CAS 41108-81-0: 1,1-Dimethylethyl 2-(trimethylsilyl)acetate

Tert-Butyl trimethylsilylacetate is an ester of a ketone and an imidazole. It is synthesized by the reaction of an enolate with isopropyl alcohol in the presence of trifluoride, which reacts with the carbonyl group to form a tertiary carbon center. This type of compound can be used as a synthetic intermediate in chemical reactions. Tert-Butyl trimethylsilylacetate can also be used as a catalyst for organic reactions, such as those that require high temperatures or boron trifluoride etherate. The biosynthesis of this compound has been studied using Daphniphyllum leaves, which are found to produce tert-butyl methylsilylacetate from acetaldehyde and methylamine.

Applications tert-Butyl (Trimethylsilyl)acetate is used to prepare lithium enolates, and is also a useful synthetic intermediate. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Rathke, M. & Elghanian, R. tert-Butyl Trimethylsilylacetate In Handbook of Reagents for Organic Synthesis: Reagents for Silicon-Mediated Organic Synthesis; Fuchs, P.; Wiley, 2011; 147-148