CAS: 41515-13-3

N-DesmethylBendamustine is a metabolite of Bendamustine. It exerts cytotoxic effects on various lymphoma cell lines and peripheral blood lymphocytes.

N-Desmethylbendamustine is a drug that is used to treat chronic lymphocytic leukemia. It inhibits tumor growth by binding to DNA, inhibiting transcription and replication of cancer cells. N-Desmethylbendamustine has been shown to be effective against pediatric patients with chronic lymphocytic leukemia, but its efficacy in adults is not well-established. The elimination half-life of the drug is 3 hours and it is eliminated via hepatic metabolism. The drug also has a low risk for cross-resistance with other chemotherapeutic drugs.