CAS 4185-01-7: (5β,12α)-12-Hydroxy-3-oxocholan-24-oic acid

Applications 3-Oxo-12a-hydroxy-5β-cholanoic Acid is a keto bile acid derivative. References Bortolini, O. et al.: Tetra., 62, 4482 (2006); Bortolini, O. et al.: J. Org. Chem., 67, 5802 (2002);

3-Oxo-12α-hydroxy-5β-cholanoic acid is a bile acid derivative, which is a type of steroid acid found naturally in bile. Bile acids, such as this compound, are synthesized in the liver from cholesterol and play a crucial role in the digestion and absorption of lipids in the small intestine. The mode of action of 3-Oxo-12α-hydroxy-5β-cholanoic acid involves interaction with cellular receptors and enzymes to regulate cholesterol metabolism, bile flow, and lipid absorption. By binding to specific nuclear receptors, it influences gene expression related to these metabolic pathways. This compound is predominantly used in research settings to study its effects on liver function, cholesterol metabolism, and gastrointestinal health. It serves as a tool in understanding the physiological and pathological roles of bile acids in various diseases, such as cholestasis, liver disease, and metabolic disorders. Scientists utilize this compound to decipher intricate biochemical pathways and explore potential therapeutic targets for conditions associated with bile acid dysregulation.