CAS 4202-14-6: Dimethyl P-(2-oxopropyl)phosphonate

Dimethyl acetylmethylphosphonate is a Reagent used together with tosyl azide in a one-pot alkynylation of aldehydes. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications Dimethyl (2-Oxopropyl)phosphonate is a common chemical reagent used in the synthesis of pharmaceuticals. Used in the synthesis of phenyl-substituted prostaglandins used as selective antiglaucoma agents. Also used in the synthesis of dipeptidyl enoates as potent rhodesain inhibitors. Rhodesain is the cysteine protease of Trypanosoma brucei parasites which cause African sleeping sickness. References Resul, B. et al.: J. Med. Chem., 36, 243 (1993); Ehmke, V. et al.: ChemMedChem., 8, 965 (2013);

Dimethyl (2-oxoprop-1-yl)phosphonate

Dimethyl acetylmethylphosphonate is a chlorinated organocatalytic reagent that is used in the Friedel-Crafts reaction. It can be used as an acceptor in the synthesis of pharmaceutical formulations and has been shown to react with chloride, triethyl orthoformate, 4-acetamidobenzenesulfonyl azide, β-unsaturated ketone, hexahydrate, trifluoromethanesulfonic acid, c1-4 alkyl aldehydes, and phosphonates. The Friedel-Crafts reaction is an organic reaction that involves the conversion of an unsaturated compound into another compound with more double bonds by adding a hydrogen atom to one of the carbons in the molecule. This process can be used for many purposes such as creating drugs or other chemicals. Dimethyl acetylmethylphosphonate is an example of a chemical that can be synthesized using this reaction.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.