N-(1-Methylethyl)-2-pyrimidinamine, also known by its CAS number 4214-72-6, is an organic compound characterized by its pyrimidine ring structure, which is a six-membered heterocyclic aromatic ring containing two nitrogen atoms at positions 1 and 3. This compound features an isopropyl group (1-methylethyl) attached to the nitrogen atom of the pyrimidine, contributing to its unique properties. It is typically a solid at room temperature and may exhibit moderate solubility in polar solvents due to the presence of the amine functional group. The compound is of interest in various fields, including medicinal chemistry, where it may serve as a building block for pharmaceuticals or as a ligand in coordination chemistry. Its reactivity is influenced by the basicity of the amine group and the electron-withdrawing nature of the pyrimidine ring, which can affect its interactions in biological systems. Safety data should be consulted for handling and usage, as with any chemical substance.

N-(1-Methylethyl)-2-pyrimidinamine

4214-72-6: 2-(Isopropylamino)pyrimidine, 2-Pyrimidinamine, N-(1-methylethyl)-, Isaxonina, Isaxonina [INN-Spanish], Isaxonine [INN], Isaxoninum, Isaxoninum [INN-Latin], N-(1-Methylethyl)-2-pyrimidinamine, N-(Isopropylamino)-2-pyrimidine, N-(propan-2-yl)pyrimidin-2-amine, N-Isopropyl-2-pyrimidinamine, Pyrimidine, 2-(isopropylamino)-, Unii-883G6Dmt63,  Isaxonine

Isopropyl-pyrimidin-2-yl-amine

N-Isopropylpyrimidin-2-amine

Applications Isaxonine is a neurotropic agent. Isaxonine prevents synaptic remodeling by suppression of the redundant nerve endings from additional axons. Isaxonine is transformed by cytochrome P 450 into reactive metabolites that lead to immunoallergic hepatitis in man.
References Becker, C.M., et. al.: Eur. Surg. Res., 18, 383 (1986); De Reuck, J., et. al.: Acta Neuropath., 72, 406 (1987); Loeper, J., et. al.: Hepatology, 9, 675 (1989)


CAS 4214-72-6: N-(1-Methylethyl)-2-pyrimidinamine

Isopropyl-pyrimidin-2-yl-amine

Ref: 10-F088600

N-Isopropylpyrimidin-2-amine

Ref: IN-DA0073MG

Isopropyl-pyrimidin-2-yl-amine

Ref: 3D-FI63880

Isaxonine

Ref: TR-I900670