CAS 422-64-0: Pentafluoropropionic acid

Pentafluoropropionic acid is a glycol ether that is used in the preparation of coumarin derivatives. It reacts with sodium carbonate and trifluoroacetic acid to form the corresponding acyl chloride, which then reacts with nitrogen atoms (e.g., ammonia) to form an amide or urea derivative. Pentafluoropropionic acid also reacts with hydrogen fluoride to form pentafluoropropane and hydrogen fluoride gas, which can be used as a propellant for aerosol sprays. Pentafluoropropionic acid binds to toll-like receptors on cancer cells and human serum, inhibiting their ability to synthesize DNA. The compound has been shown to inhibit tumor growth in mice by blocking the formation of cancer tissues.

Stability Volatile Applications 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid-13C is the labeled analogue of 2,​2,​3,​3,​3-​Pentafluoropropanoic Acid (P227235), which is used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [(R)-(amino)(oxo)(fluorophenyl)butyl]tetrahydro(fluoroethyl)-1,2,4-triazolo[4,3-a]pyrazine using (fluoro)propanoic acid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Manyanga, V., et al.: J. Pharm. Biomed. Analysis, 45, 257 (2007); Kim, D., et al.: J. Med. Chem., 48, 141 (2005)

Pentafluoropropanoic acid

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Pentafluoropropanoic acid

Pentafluoropropionic acid, min. 97%

Stability Volatile Applications Pentafluoropropionic acid (Perfluoropropionic acid) was used in the analysis of gentamicin with Gemini column by liquid chromatographic (LC) methods. It was also used to prepare [(R)-(amino)(oxo)(fluorophenyl)butyl]tetrahydro(fluoroethyl)-1,2,4-triazolo[4,3-a]pyrazine using (fluoro)propanoic acid. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Manyanga, V., et al.: J. Pharm. Biomed. Analysis, 45, 257 (2007); Kim, D., et al.: J. Med. Chem., 48, 141 (2005)