CAS 42278-67-1: Borate(1-), hydrotris(2-propanolato)-, potassium (1:1), (T-4)-

Potassium triisopropoxyborohydride (K-iPr-BH) is a synthetic chemical compound that inhibits the reaction of hydroxyl groups with carbonyl groups in coumarin derivatives. It has shown an inhibitory effect on the synthesis of DNA in cancer cells and is used as a diagnostic tool for detecting cancerous cells. K-iPr-BH reacts with the nitrogen atoms in streptavidin to form a stable product, which can then be detected by various methods. The reaction products are characterized by their functional groups, such as hydroxyl, carbonyl, and methyl nicotinate. This reagent also has an inhibitory effect on the reaction between amines and nitroso compounds.

Triisopropoxyborohydride is an organolithium reagent that can be used for asymmetric synthesis. It is a chiral compound, which means it has no plane of symmetry. Triisopropoxyborohydride is a nucleophilic reagent that reacts with electrophiles, such as chlorides or imidoyl groups, to form new carbon-carbon bonds. It can also be used in the synthesis of alkene molecules and yields high yields in reactions with diborane. The trialkylboranes are activated by the lithium ion to generate a nucleophilic species, which reacts with the electrophile to form a new carbon-carbon bond. This reaction will happen faster if the functional groups on both reactants are similar because of the electron withdrawing effect on the electrophile and electron donating effect on the nucleophile.