CAS 4254-15-3: (+)-1,2-Propanediol

Applications (S)-(+)-Propane-1,2-diol is a general reagent used in organic synthesis. (S)-(+)-Propane-1,2-diol is used in the synthesis of anti-tuberculosis agents inspired by BTZ043 for MDR resistant strains. References Tiwari, R. et al.: ACS Med. Chem. Lett., 5, 587 (2014); Tiwari, R. et al.: J. Am. Chem. Soc., 135, 3539 (2013);

(S)-(+)-1,2-Propanediol acts as an organic solvent and diluent used in pharmaceutical preparations. It is also used as a chiral synthetic intermediate and substrate for enzyme studies. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

(S)-(+)-1,2-Propanediol ((2S)-propane-1,2-diol) is an endogenous compound produced by the engineered bacterium Lactococcus lactis.

(S)-(+)-1,2-Propanediol

(S)-(+)-1,2-Propanediol is a diol that is a chemical compound with the molecular formula HOCHCHOH. It has an asymmetric carbon atom and can exist as two enantiomers (S)-(+)-1,2-propanediol and (R)-(-)-1,2-propanediol. The compound is produced in the laboratory by oxidation of propylene with hydrogen peroxide in the presence of a metal catalyst. It undergoes dehydration reactions to form sugars such as erythritol and xylitol. This process also occurs naturally in some plants and bacteria where glucose is oxidized to form glycerol. The conversion of propane-1,2-diol to glycerol is catalyzed by alcohol dehydrogenase from yeast or fungi such as Candida boidinii or Candida kefyr. It also reacts with other molecules such as proteins via amide formation to form new compounds called a