CAS 42835-25-6: Flumequine

FLUMEQUINE CRS

Applications Fluorinated quinolone antibacterial.This compound is a contaminant of emerging concern (CECs). References Stilwell, G., et al.: Antimicrob. Agents Chemother., 7, 483 (1975), Rohlfing, S.R., et al.: J. Antimicrob. Chemother., 3, 615 (1977),

Inhibits topoisomerases in Gram-negative bacteria. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Flumequine

Flumequine is a new fluorinated quinolone antibiotic that has been shown to be effective against a wide range of Gram-negative and Gram-positive bacteria. It inhibits bacterial growth by binding to the 30S ribosomal subunit, thereby preventing mRNA synthesis. Flumequine has also been shown to be effective against Mycobacterium tuberculosis in vitro, but not in vivo. The high values for fluorescence detection of this drug have been demonstrated using an analytical method that measures the reaction between fluorescamine and flumequine. This reaction produces a fluorescent product that can be measured by a fluorescence detector. Flumequine may also bind to human serum proteins, which may interfere with its efficacy in vivo.

Flumequine (R-802) is a broad-spectrum antibiotic targeting DNA gyrase and topoisomerase IV in Gram-positive and Gram-negative bacteria.