2-Fluorobenzeneacetyl chloride, with the CAS number 451-81-0, is an organic compound characterized by the presence of both a fluorine atom and an acyl chloride functional group. It features a benzene ring substituted with a fluorine atom at the ortho position relative to the acetyl chloride group. This compound is typically a colorless to pale yellow liquid with a pungent odor, indicative of its reactivity. As an acyl chloride, it is highly reactive, particularly with nucleophiles, making it useful in various synthetic applications, including the preparation of amides and esters. The presence of the fluorine atom can influence the compound's reactivity and polarity, potentially enhancing its electrophilic character. 2-Fluorobenzeneacetyl chloride is also sensitive to moisture and should be handled with care, as it can hydrolyze to form hydrochloric acid and the corresponding carboxylic acid. Proper safety precautions, including the use of personal protective equipment, are essential when working with this compound due to its corrosive nature.

2-Fluorobenzeneacetyl chloride

451-81-0: 2-(2'-Fluorophenyl)acetyl chloride, 2-Fluorobenzeneacetyl chloride, Acetyl chloride, (o-fluorophenyl)-, Benzeneacetyl chloride, 2-fluoro-, o-Fluorophenylacetyl chloride

2-Fluorophenylacetylchloride

2-Fluorophenylacetyl chloride is a chlorinating agent that selectively adds fluorine to carbonyl groups. It is used in the synthesis of homochiral synthons and in the production of fluorinated pharmaceuticals. The stereochemical outcome depends on the enolate employed, with an enolate derived from a chiral ketone or alcohol typically giving rise to a single diastereomer. The stereoselective addition of 2-fluorophenylacetyl chloride to alkenes is accomplished using a catalytic system that employs cyclopentadiene as the catalyst.

CAS 451-81-0: 2-Fluorobenzeneacetyl chloride

2-Fluorophenylacetylchloride

Ref: 10-F038271

2-Fluorophenylacetyl chloride

Ref: 3D-FF97431

2-(2-Fluorophenyl)acetyl chloride

Ref: IN-DA003ERQ

2-Fluorophenylacetyl chloride

Ref: 54-PC1581