4-Chloro-2-fluoro-1-methoxybenzene, with the CAS number 452-09-5, is an aromatic compound characterized by the presence of a methoxy group (-OCH3), a chlorine atom, and a fluorine atom attached to a benzene ring. This compound typically exhibits a colorless to pale yellow liquid form and has a distinct aromatic odor. Its molecular structure contributes to its chemical reactivity, making it useful in various organic synthesis applications. The presence of both electronegative halogens (chlorine and fluorine) can influence its reactivity and polarity, potentially enhancing its solubility in organic solvents. Additionally, 4-chloro-2-fluoro-1-methoxybenzene may participate in electrophilic aromatic substitution reactions, making it a valuable intermediate in the synthesis of pharmaceuticals and agrochemicals. Safety data indicates that, like many halogenated compounds, it should be handled with care due to potential toxicity and environmental concerns. Proper storage and disposal methods are essential to mitigate any risks associated with its use.

4-Chloro-2-fluoro-1-methoxybenzene

452-09-5: 1-Chloro-3-fluoro-4-methoxybenzene, 2,4-Difluoro-1-Methoxybenzene, 4-Chloro-2-Fluoro-1-Methoxybenzene, Anisole, 4-chloro-2-fluoro-, Benzene, 4-chloro-2-fluoro-1-methoxy-, NSC 10330, 4-Chloro-2-fluoroanisole

4-Chloro-2-Fluoroanisole is a colorless liquid that has a sweet odor. It is used as an intermediate in the synthesis of other chemical compounds. 4-Chloro-2-Fluoroanisole can be obtained by reacting carbon tetrachloride with fluorine gas, or by reacting chloroform with hydrogen fluoride in the presence of zinc chloride. This compound has been shown to have a molecular weight of 155.4 g/mol and the following spectral data:

1H NMR (400 MHz, CDCl3) δ 7.77 (d, J=8.5 Hz, 2H), 7.67 (d, J=8.5 Hz, 2H), 6.78 (s, 1H), 3.51 (s, 3H).

13C NMR (100 MHz, CDCl3) δ 127.6, 127.0 126.8

CAS 452-09-5: 4-Chloro-2-fluoro-1-methoxybenzene

4-Chloro-2-Fluoroanisole

Ref: 3D-FC77777

4-Chloro-2-fluoro-1-methoxybenzene

Ref: IN-DA003L33

4-Chloro-2-fluoroanisole

Ref: 54-PC7423

4-Chloro-2-fluoroanisole

Ref: 10-F013259