CAS: 4530-21-6

Enniatin A1

Enniatin A1, a cyclic hexadepsipeptide from Fusarium, induces apoptosis and disrupts ERK, inhibiting ACAT (IC50: 49 μM).

Enniatin A1 is a cyclic hexadepsipeptide, which is a secondary metabolite produced by various Fusarium species. This compound is primarily derived from Fusarium fungi and exhibits notable bioactivity due to its ionophoric properties. The mode of action involves its ability to disrupt ion gradients across cellular membranes. Enniatin A1 functions by forming complexes with cations, particularly alkali and alkaline earth metal ions, facilitating their transport across lipid membranes and ultimately perturbing cellular homeostasis. The uses and applications of Enniatin A1 are broad, particularly in mycological and pharmacological research. It is commonly studied for its antifungal properties, as it influences the bioenergetics of fungal cells, leading to their growth inhibition or death. Furthermore, its potential anticancer activity is an area of active investigation, where it is assessed for its ability to induce apoptosis in cancer cells. Enniatin A1 serves as an essential tool in studying ion transport mechanisms and as a lead compound in the development of novel antifungal and anticancer agents. Its biogenic origin and specific mode of action make it a molecule of significant interest in various scientific domains.