3-(1H-pyrazol-5-yl)pyridine, with the CAS number 45887-08-9, is an organic compound characterized by its unique structure, which features a pyridine ring substituted with a pyrazole moiety. This compound typically exhibits a pale to light yellow solid appearance and is soluble in polar organic solvents. It is known for its potential applications in medicinal chemistry, particularly as a building block in the synthesis of various bioactive molecules. The presence of both the pyridine and pyrazole rings contributes to its ability to engage in hydrogen bonding and coordination with metal ions, making it of interest in coordination chemistry and catalysis. Additionally, the compound may exhibit biological activity, including antimicrobial or anti-inflammatory properties, although specific biological data may vary. Its stability and reactivity can be influenced by the functional groups present, making it a versatile compound in synthetic organic chemistry. Overall, 3-(1H-pyrazol-5-yl)pyridine is a valuable compound for research and development in various chemical and pharmaceutical applications.

3-(1H-pyrazol-5-yl)pyridine

45887-08-9: 3-(1H-Pyrazol-3-yl)pyridine, pyridine, 3-(1H-pyrazol-3-yl)-

3-(1H-Pyrazol-3-yl)pyridine (PPY) is a potent and selective inhibitor of cyclooxygenase-2 (COX-2). PPY has been shown to inhibit COX-2 activity with an IC50 value of 0.4 μM. PPY does not inhibit COX-1, which is responsible for the production of prostaglandins that maintain the normal function of the stomach and intestine. PPY also has a low safety profile, with no significant effects on the heart or kidneys in animal studies. The compound is being developed as a potential treatment for inflammatory diseases such as rheumatoid arthritis. The drug was originally discovered by screening chemical libraries for compounds that could inhibit COX-2 activity. Molecular docking studies have shown that PPY binds to the active site of COX-2, preventing access to substrates and thereby inhibiting catalytic activity.

CAS 45887-08-9: 3-(1H-pyrazol-5-yl)pyridine

3-(1H-Pyrazol-3-yl)pyridine

Ref: 3D-FP122768

3-(1H-Pyrazol-3-yl)pyridine

Ref: 10-F208954

3-(1H-PYRAZOL-3-YL)PYRIDINE

Ref: IN-DA00D8FK

3-(1H-Pyrazol-3-yl)pyridine

Ref: 54-OR32805