CAS 4673-26-1: Diphenyleneiodonium chloride

Diphenyleneiodonium Chloride

Applications Diphenyleneiodonium Chloride binds strongly to flavoproteins and thus inhibits NO synthase, NADG reductase and NADPH oxidase.Diphenyleneiodonium Chloride solubility: 5 mg in 1.7 mL of H2O:DMSO 40:60; 10 mg in 1.1 mL H2O:DMSO 10:90 References Jones, et al.: Biochem J., 265, 95 (1990), Stuehr, et al.: FASEB J., 5, 98 (1991), Wang, Y-X, et al.: J. of Pharmacology & Exp. Therap., 265, 1 , 263 (1993) Circulation Research, 74 (6), 1142 (1994), Cruz, T.F., et al.: J.B.C., 271, 26, 15703(1996)

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Diphenyleneiodonium chloride is a diphenyliodonium salt that inhibits neuronal death and induces pluripotent stem cells. It has been shown to activate toll-like receptor 4 (TLR4) which initiates the inflammatory response, leading to the activation of growth factor-β1 and polymerase chain reactions. This compound also has an oral hypoglycemic effect and can be used as an antidiabetic drug. Diphenyleneiodonium chloride has also been shown to induce oxidative cell death in cancer cells by inhibiting the production of NADPH oxidase, which is required for caspase-independent cell death.

Diphenyleneiodonium chloride

Diphenyleneiodonium chloride (DPI) inhibits iNOS & eNOS (IC50: 50 nM & 0.3 μM) and has wide-ranging bactericidal properties.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.