CAS 472-11-7: Ruscogenin
Formula:C27H42O4
InChI:InChI=1S/C27H42O4/c1-15-7-10-27(30-14-15)16(2)24-22(31-27)13-21-19-6-5-17-11-18(28)12-23(29)26(17,4)20(19)8-9-25(21,24)3/h5,15-16,18-24,28-29H,6-14H2,1-4H3/t15-,16+,18-,19-,20+,21+,22+,23-,24+,25+,26+,27-/m1/s1
InChI key:InChIKey=QMQIQBOGXYYATH-IDABPMKMSA-N
SMILES:C[C@@]12[C@@]3([C@@](O[C@@]4([C@H]3C)CC[C@@H](C)CO4)(C[C@]1([C@]5([C@](CC2)([C@]6(C)C(=CC5)C[C@@H](O)C[C@H]6O)[H])[H])[H])[H])[H]
Synonyms:- (1beta,3beta,22xi,25R)-spirost-5-en-1,3-diol
- (1beta,3beta,25R)-spirost-5-en-1,3-diol
- (1β,3β,25R)-Spirost-5-ene-1,3-diol
- 25<span class="text-smallcaps">D</span>-Spirost-5-ene-1β,3β-diol
- 25R-Ruscogenin
- Ruscogenin
- Ruscogenine
- Spiro[8H-naphth[2′,1′:4,5]indeno[2,1-b]furan-8,2′-[2H]pyran], spirost-5-ene-1,3-diol deriv.
- Spirost-5-ene-1,3-diol, (1β,3β,25R)-
- Spirost-5-ene-1β,3β-diol, (25R)-
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Found 11 products.
Ruscogenin
CAS:Formula:C27H42O4Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:430.63Ruscogenin
CAS:Ruscogenin is a steroidal saponin, which is derived from the underground parts of plants belonging to the genus *Ruscus*, commonly known as butcher's broom. This compound is extracted primarily from the rhizomes of these plants. Its mode of action involves modulating inflammatory pathways by inhibiting the release of pro-inflammatory cytokines, thereby reducing inflammation. Additionally, ruscogenin has been observed to enhance vascular integrity and reduce capillary permeability. Given its pharmacological profile, ruscogenin is widely studied for its potential therapeutic applications, particularly in the treatment of chronic venous insufficiency, hemorrhoids, and lymphatic disorders. By improving venous tone and decreasing vascular permeability, it has been shown to alleviate symptoms associated with poor circulation and edema. Furthermore, its anti-inflammatory properties make it a subject of interest for potential use in managing inflammatory conditions. The ongoing research continues to explore its broader implications in vascular health and as a potential adjunct in the treatment of inflammatory diseases.Formula:C27H42O4Purity:Min. 95%Molecular weight:430.62 g/molRuscogenin
CAS:Applications A major steroidal sapogenin from Radix ophiopogon japonicus with robust anti-inflammatory and anti-thrombotic activities. Studies suggest that it inhibits adhesion of leukocytes to a human umbilical vein endothelial cell line (ECV304) injured by tumor necrosis factor-α (TNF-α) in a concentration-dependent manner. References Huang, Y. et al.: Drug Dev. Res., 69, 196 (2008); Huang, Y. et al.: J. Pharmacol. Sci., 108, 198 (2008); Song, J. et al.: J. Pharmacol. Sci., 113, 409 (2010);Formula:C27H42O4Color and Shape:NeatMolecular weight:430.62Ruscogenin
CAS:Oxygen-heterocyclic compoundFormula:C27H42O4Purity:≥ 95.0 % (HPLC)Color and Shape:PowderMolecular weight:430.63Ruscogenin
CAS:Ruscogenin exerts significant anti-inflammatory and anti-thrombotic activities.Ruscogenin significantly attenuates LPS-induced acute lung injury (ALI )via inhibiting expressions of TF and iNOS and NF-κB p65 activation, it inhibits activation of neutrophil through cPLA 2 , PAK, Akt, MAPKs, cAMP, and PKA signaling pathways.Formula:C27H42O4Purity:95%~99%Molecular weight:430.629Ruscogenin
CAS:Ruscogenin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.Formula:C27H42O4Purity:(HPLC) ≥95%Color and Shape:PowderMolecular weight:430.63
