CAS 4740-24-3: 4-(Butylamino)benzoic acid

Aromatic amino-acids and their esters,other than those

4-(Butylamino)benzoic acid

4-(Butylamino)benzoic acid is a non-steroidal anti-inflammatory drug (NSAID) that has been used to treat pain. It is a prodrug, which is metabolized in the liver to 4-(butylamino)-phenylacetic acid, its active form. The 4-(butylamino)benzoic acid molecule has a hydrophobic effect and binds to chloride ions. This binding inhibits the production of prostaglandins, which are mediators of pain. 4-(Butylamino)benzoic acid also reduces the activity of plasma cells that produce antibodies and increases the activity of lymphocytes and platelets, leading to an increase in immunoglobulin levels.

Applications 4-(Butylamino)benzoic Acid is an intermediate used to synthesize 5-nitrothiophene derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus. References Masunari, A., et al.: Bioorg. Med. Chem., 15, 4229 (2007);