CAS 4752-10-7: 1,4-Dichlorophthalazine

It is used as pharmaceutical intermediate. Benzoylthiophenes are allosteric enhancers (AE) of agonist activity at the A1 adenosine receptor. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

1,4-Dichlorophthalazine

1,4-Dichlorophthalazine (1,4-DCP) is a synthetic compound that inhibits the activity of ns3 protease. It is a reactive chlorine atom with two hydroxyl groups on the benzene ring and one alkynyl group on the pyrimidine ring. 1,4-DCP has been shown to inhibit growth factor receptor signals in cells. The structure of 1,4-DCP includes an ethynyl group which may contribute to its binding affinity for the kinase receptor. 1,4-DCP inhibits cancer cell proliferation and inflammatory bowel disease by blocking growth factor receptors. 1,4-DCP also blocks protein synthesis by inhibiting the activity of an enzyme called crth2.