CAS 477-48-5: (-)-Picropodophyllone
Formula:C22H20O8
InChI:InChI=1S/C22H20O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-19H,8-9H2,1-3H3/t13-,18+,19+/m0/s1
InChI key:InChIKey=ISCQYPPCSYRZOT-MJXNMMHHSA-N
SMILES:O=C1[C@]2([C@@H](C=3C(C(=O)[C@]2(CO1)[H])=CC4=C(C3)OCO4)C5=CC(OC)=C(OC)C(OC)=C5)[H]
Synonyms:- (-)-Picropodophyllone
- (5aR,8aS,9R)-5a,6,8a,9-Tetrahydro-9-(3,4,5-trimethoxyphenyl)furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, (5aR,8aS,9R)-
- Furo[3′,4′:6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, [5aR-(5aα,8aα,9α)]-
- Picropodophyllotoxon
- Picropodophyllotoxone
- furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxole-5,8-dione, 5a,6,8a,9-tetrahydro-9-(3,4,5-trimethoxyphenyl)-, (5aR,8aS,9R)-
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Found 5 products.
Picropodophyllone
CAS:Picropodophyllone is a naturally occurring podophyllotoxin analog, which is derived primarily from the roots and rhizomes of plants in the Podophyllum genus. This compound exhibits its biological activity by interfering with microtubule assembly and cell division, mechanisms akin to those observed in other lignan-based compounds. The mode of action of picropodophyllone involves binding to tubulin, thereby inhibiting polymerization necessary for microtubule formation. This disruption in microtubule dynamics leads to cell cycle arrest in the metaphase, hindering the proliferation of rapidly dividing cells. Applications of picropodophyllone are primarily in research settings, particularly in studies focused on anti-cancer therapies. Its cytotoxic properties make it a candidate for further investigation in the development of chemotherapeutic agents. Moreover, the structural nuances of picropodophyllone contribute to a deeper understanding of lignan-related cytotoxic mechanisms, providing valuable insights into the design of novel drugs targeting various forms of cancer.Formula:C22H20O8Purity:Min. 95%Molecular weight:412.4 g/molPicropodophyllotoxone
CAS:Formula:C22H20O8Purity:≥ 98.0%Color and Shape:White to off-white solidMolecular weight:412.39Picropodophyllone
CAS:Picropodophyllone is one of the lignans from the roots of D. aurantiocaulis and D. pleianthum.Formula:C22H20O8Purity:98.49%Color and Shape:SolidMolecular weight:412.39
