CAS 477-57-6: 1-Isotetrandrine

Isotetrandrine is a small molecule inhibitor, on various aspects of LPS-induced inflammation in vitro and in vivo. It dose-dependently suppresses the severity of LPS-induced ALI by inactivation of MAPK and NF-κB, which may involve the inhibition of tissue

Isotetrandrine is a bis-benzylisoquinoline alkaloid, which is derived from traditional herbal sources, specifically the Stephania genus of plants. Its mode of action involves the inhibition of various ion channels, including calcium channels, which plays a significant role in its pharmacological profile. This compound demonstrates a range of biological activities, such as anti-inflammatory and antineoplastic effects, among others. Its ability to modulate ion channels makes it a subject of interest for therapeutic applications, particularly in the management of cardiovascular diseases, cancer, and immune-related conditions. The exploration of Isotetrandrine's effects on signal transduction pathways and its potential to alter cellular responses to external stimuli have made it a valuable compound in pharmacological research. In scientific investigations, Isotetrandrine is often utilized to study cellular mechanisms and to develop novel therapeutic strategies, given its multifaceted actions and natural origin. The study of its interactions and effects may contribute to the advancement of drug discovery and development, particularly in areas where current treatments are inadequate.

Applications Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2. References Abe, T., et al.: Toxicon, 38, 1803 (2003); Matsuno, T., et al.: Biochem. Pharmacol., 36, 1613 (1987); Matsuno, T., et al.: Igaku to Yakugaku, 16, 445 (1986)