CAS 4795-29-3: Tetrahydrofurfurylamine

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Tetrahydrofurfurylamine was used to study specific interactions between unlike molecules by calculating the molar excess enthalpies. It can be used to produce N-tetrahydrofurfuryl-phthalimide with phthalic acid anhydride by heating. This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

2-(Aminomethyl)tetrahydrofuran

Applications Tetrahydro-2-furanmethanamine is used in the synthesis of novel topoisomerase I targeting anti-cancer agents with mild to potent cytotoxic activity. Also used in the discovery and synthesis of orally bioavailable stearoyl-CoA desaturase 1 inhibitors References Lopez-Rodriguez, M. et al.: 44, 4504 (2001); Liu, G. et al.: J. Med. Chem., 50, 3086 (2007);

2-Tetrahydrofurfurylamine (2TF) is an organic compound that belongs to the class of inorganic acids. It is a reactive and light-emitting molecule that has been used as a substrate molecule in molecular docking analysis. 2TF is also used as a reactive intermediate in the preparation of detergents. The reaction mechanism involves the formation of an ethylene diamine by nucleophilic attack on the carbonyl group, followed by oxidative addition of the hydroxyl group to the nitrogen atom. This process leads to the formation of a coordination complex with a geometry that favours two nitrogen atoms and two oxygen atoms, which are further coordinated by four carbon atoms. 2TF can be found in several infectious diseases, such as tuberculosis and leprosy, where it has been shown to inhibit cell growth through inhibition of protein synthesis and DNA replication.