CAS 481-42-5: Plumbagin

Applications Plumbagin induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Klotz, L., et al.: Molecules, 19 14902 (2014); Gupta, S., et al.: Cancer Metastasis Rev., 29, 405 (2010); Schramm, A., et al.: Vascul. Pharmacol., 56, 216 (2012)

Plumbagin is a quinonoid compound, which is a secondary metabolite found in the roots of Plumbago species. This compound is characterized by its naphthoquinone structure, which is responsible for its diverse biological activities. Plumbagin exerts its effects primarily through the generation of reactive oxygen species (ROS), modulation of cellular signaling pathways, and inhibition of specific enzyme functions, such as topoisomerases. These actions result in the modulation of cell proliferation, apoptosis, and inflammation, making Plumbagin a compound of interest for various biomedical applications. Recent research has explored its potential in cancer therapy due to its ability to induce apoptosis in tumor cells while sparing normal cells. Additionally, Plumbagin exhibits antimicrobial, anti-inflammatory, and antioxidant properties, further broadening its applications. Continued investigations into the molecular mechanisms of Plumbagin are crucial for understanding its full therapeutic potential and for the development of novel therapeutic strategies targeting various diseases.

Plumbagin

Applications Plumbagin-d3 is labelled Plumbagin (P627000) which induces apoptosis in cancer cells. It also inhibits NADPH oxidase 4 in a time- and dose-dependent manner. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package References Klotz, L., et al.: Molecules, 19 14902 (2014); Gupta, S., et al.: Cancer Metastasis Rev., 29, 405 (2010); Schramm, A., et al.: Vascul. Pharmacol., 56, 216 (2012)

Plumbagin

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Plumbagin, a yellow dye from naphthoquinone, is isolated from Plumbago and found in Drosera, Nepenthes, and black walnut drupe.

Quinone

Plumbagin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

5-Hydroxy-2-methylnaphthalene-1,4-dione