CAS 483-04-5: Ajmalicine

Natural alkaloid

Ajmalicine

Applications Antihypertensive, anti-ischemic. References Caillet, S., et al.: Food Chem., 124, 1699 (2010), Dresen, S., et al.: Anal. Bioanal. Chem., 396, 2425 (2010), Ferreres, F., et al.: J. Pharm. Biomed. Anal., 51, 65 (2010),

Raubasine is an indole alkaloid, which is naturally sourced from the plant Rauvolfia serpentina as well as other Rauvolfia species. Its mode of action primarily involves the interaction with adrenergic receptors, where it acts as an antagonist. By blocking these receptors, Raubasine influences the sympathetic nervous system, leading to vasodilation and a subsequent hypotensive effect. This mechanism is primarily leveraged in pharmacological research to study cardiovascular effects and sympathetic nervous system modulation. The uses and applications of Raubasine are primarily centered around its ability to modulate blood pressure and its potential neuroprotective effects. It has been extensively studied in the context of hypertension and is considered for its potential benefits in treating certain types of vascular-related neurological conditions. The interest in Raubasine extends to neuropharmacological research, where its effects on cerebral blood flow and neuronal health are of significance. While its use in clinical settings is limited, its pharmacological properties make it a compound of interest for further research and development within scientific and medical communities.

Ajmalicine (Raubasine): Blocks α1-adrenoceptor, non-competitive nicotine receptor inhibitor (IC50=72.3 μM), anti-hypertensive, sedative.