CAS 486-35-1: Daphnetin

Lactone

Daphnetin analytical standard provided with chromatographic purity, to be used as reference material for qualitative determination.

7,8-Dihydroxycoumarin is a naturally occurring coumarin, which is derived from plants and certain fungi. It possesses a distinct chemical structure characterized by a benzopyrone core with hydroxyl groups at the 7th and 8th positions, contributing to its distinct biochemical properties. The mode of action of 7,8-Dihydroxycoumarin is largely attributed to its ability to act as a potent antioxidant, scavenging free radicals and chelating metal ions, thus mitigating oxidative stress at the cellular level. In scientific research, 7,8-Dihydroxycoumarin is extensively studied for its potential as a therapeutic agent due to its diverse biological activities. It exhibits anti-inflammatory, antimicrobial, and anticoagulant properties, making it a valuable candidate for various biomedical applications. Additionally, its role in modulating enzyme activities and signaling pathways further broadens its scope in pharmacological studies. Researchers are keenly investigating its use in developing novel treatments for diseases associated with oxidative stress and inflammation. The precise mechanisms and broad applications of 7,8-Dihydroxycoumarin make it a subject of significant interest within the scientific community.

7,8-Dihydroxycoumarin

Daphnetin (7,8-Dihydroxycoumarin), a natural coumarin derivative, is a protein kinase inhibitor with inhibitory for EGFR (IC50: 7.67 μM), PKA (IC50: 9.33 μM),

7,8-Dihydroxycoumarin (7,8-DHC) is a natural compound that has been shown to inhibit the expression of the P-glycoprotein (Pgp) gene and protein. 7,8-DHC binds to the response element in the Pgp gene promoter and inhibits transcriptional activity. This inhibition of transcription prevents the production of new Pgp proteins, which leads to an increase in drug resistance. 7,8-DHC also has been shown to bind to bcl-2 protein in vitro and prevent its release from mitochondria. This prevents apoptosis by inhibiting mitochondrial membrane permeability. Coumarin derivatives have been shown as potential therapeutic agents for bowel diseases such as ulcerative colitis and Crohn's disease. Daphnetin, a coumarin derivative found in dandelion roots, has shown promise as a treatment for colitis in mice models.

Daphnetin