CAS 487-24-1: 7-hydroxy-2-(4-methoxyphenyl)-4-benzopyrone

Pratol

Pratol is a synthetic antiparasitic agent, which is chemically synthesized from readily available organic precursors. It functions by disrupting the vital metabolic pathways of the targeted parasites, specifically inhibiting certain enzymes vital for parasite survival. Pratol's mode of action involves binding to the active site of these enzymes, effectively halting the necessary biochemical transformations and leading to the death of the parasite. In laboratory settings, Pratol is utilized extensively for research purposes, particularly in studies related to parasitic infections in mammalian models. Its effectiveness in inhibiting parasite growth makes it a valuable tool for elucidating the lifecycle and biology of numerous parasitic organisms. Furthermore, Pratol finds application in evaluating the efficacy of broader antiparasitic treatment protocols. Despite its utility within scientific research, rigorous standardization and control measures are imperative when using Pratol, given its potent bioactive properties and the necessity to confirm specificity and safety for experimental and eventual therapeutic applications.

Pratol analytical standard provided with w/w absolute assay, to be used for quantitative titration.

Pratol (7-Hydroxy-4'-methoxyflavone) significantly increased melanin content and tyrosinase activity in the cells without being cytotoxic.

Applications Pratol is an O-methylated flavone which is shown to induce melanogenesis in B16F10 melanoma cells. References Chung, Y. et al.: Molecules, 22, 1704 (2017);