CAS 488832-69-5: Elesclomol
Formula:C19H20N4O2S2
InChI:InChI=1S/C19H20N4O2S2/c1-22(18(26)14-9-5-3-6-10-14)20-16(24)13-17(25)21-23(2)19(27)15-11-7-4-8-12-15/h3-12H,13H2,1-2H3,(H,20,24)(H,21,25)
InChI key:InChIKey=BKJIXTWSNXCKJH-UHFFFAOYSA-N
SMILES:C(N(NC(CC(NN(C(=S)C1=CC=CC=C1)C)=O)=O)C)(=S)C2=CC=CC=C2
Synonyms:- 1,3-Bis[2-methyl-2-(phenylthioxomethyl)hydrazide]propanedioic acid
- 1-N′,3-N′-Bis(benzenecarbonothioyl)-1-N′,3-N′-dimethylpropanedihydrazide
- Gsk 842879A
- N'~1~,N'~3~-dimethyl-N'~1~,N'~3~-bis(phenylcarbothioyl)propanedihydrazide
- NSC 174939
- Propanedioic acid, 1,3-bis[2-methyl-2-(phenylthioxomethyl)hydrazide]
- Propanedioic acid, bis[2-methyl-2-(phenylthioxomethyl)hydrazide]
- Sta 4783
- Elesclomol
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Found 5 products.
Elesclomol
CAS:Elesclomol (STA-4783) is an oxidative stress inducer and a highly lipophilic copper ion carrier.Formula:C19H20N4O2S2Purity:97.17% - 99.51%Color and Shape:SolidMolecular weight:400.52Elesclomol
CAS:Elesclomol is an investigational anticancer agent, which is a small-molecule compound. It functions by targeting the cellular oxidative stress pathway; specifically, it enhances the production of reactive oxygen species (ROS) within cancer cells. By elevating ROS levels beyond the threshold tolerable by cancer cells, Elesclomol induces apoptosis through the disruption of mitochondrial function, making it selective for environments with heightened oxidative stress. Originally sourced from proprietary chemical libraries and identified through its potent cytotoxic effects in vitro, Elesclomol's mechanism leverages the inherent oxidative susceptibility of certain cancer phenotypes. Its primary action involves the transfer of electrons from ferrous ions, leading to the disproportionate accumulation of ROS, disturbing the delicate redox balance essential for cancer cell survival. Elesclomol has been studied in combination with other chemotherapeutic agents and has shown potential in treating various malignancies, particularly melanoma and other cancers characterized by increased oxidative stress. Despite its promise, further investigation is warranted to fully elucidate its therapeutic index and integration into oncological treatment regimens.Formula:C19H20N4O2S2Purity:Min. 95%Color and Shape:PowderMolecular weight:400.52 g/molN'1,N'3-Dimethyl-N'1,N'3-Di(Phenylcarbonothioyl)Malonohydrazide
CAS:N'1,N'3-Dimethyl-N'1,N'3-Di(Phenylcarbonothioyl)MalonohydrazidePurity:98%Molecular weight:400.52g/mol
