CAS 494772-86-0: 2-Thiophenecarboxamide,3-[(aminocarbonyl)amino]-5-[4-(4-morpholinylmethyl)phenyl]-

3-[(Aminocarbonyl)amino]-5-[4-(morpholin-4-ylmethyl)phenyl]thiophene-2-carboxamide is a chemical inhibitor that inhibits the activity of kinases. It has been shown to be cytotoxic against cancer cells and to induce apoptosis through a number of different mechanisms. 3-[(Aminocarbonyl)amino]-5-[4-(morpholin-4-ylmethyl)phenyl]thiophene-2-carboxamide binds to DNA and induces DNA repair, which can lead to cell death. This drug also has an anti-inflammatory effect, which may be due to its ability to inhibit pro-inflammatory cytokines such as TNFα and IL1β.

CAY10657 has a wide range of applications in life science related research.

Applications 3-[(Aminocarbonyl)amino]-5-[4-(4-morpholinylmethyl)phenyl]-2-thiophenecarboxamide is a transforming growth factor (TGF)-β-activated kinase 1 (TAK-1) inhibitor. 3-[(Aminocarbonyl)amino]-5-[4-(4-morpholinylmethyl)phenyl]-2-thiophenecarboxamide has potential use in the treatment of certain lymphomas that are particularly susceptible to TAK1 inhibitors such as B cell tumors, solid tumors, or T cell leukemias.