CAS 49627-27-2: Sulindac sulfide
Formula:C20H17FO2S
InChI:InChI=1S/C20H17FO2S/c1-12-17(9-13-3-6-15(24-2)7-4-13)16-8-5-14(21)10-19(16)18(12)11-20(22)23/h3-10H,11H2,1-2H3,(H,22,23)/b17-9-
InChI key:InChIKey=LFWHFZJPXXOYNR-MFOYZWKCSA-N
SMILES:C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(SC)C=C3
Synonyms:- (1Z)-5-Fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid
- (Z)-Sulindac sulfide
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-, (Z)-
- 1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-, (1Z)-
- Sulindac sulfide
- Sulindac sulfide, (Z)-
- cis-Sulindac sulfide
- (Z)-5-Fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-1H-indene-3-acetic acid
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Found 10 products.
Z-Sulindac sulphide
CAS:(Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid is a potent inhibitor of protein synthesis. It has been shown to inhibit the activity of sulindac sulfide, a cyclase inhibitor and nonsteroidal anti-inflammatory agent, in human polymorphonuclear leukocytes and cancer cells. (Z)-5-Fluoro-2-methyl-1-[p-(methylthio)benzylidene]indene-3-acetic acid also inhibits the mitochondrial membrane potential and reduces the growth of cancer cells by inhibiting proteins that are involved in cell proliferation.Formula:C20H17FO2SPurity:Min. 95%Color and Shape:PowderMolecular weight:340.41 g/molSulindac EP Impurity C (Sulindac USP Related Compound C, Sulindac Sulfide)
CAS:Formula:C20H17FO2SColor and Shape:Yellow SolidMolecular weight:340.41Sulindac Related Compound C ((Z)-2-{5-fluoro-2-methyl-1-[4-(methylthio)benzylidene]-1H-inden-3-yl}acetic acid)
CAS:Other aromatic organo-sulfur compounds (excluding pesticides)Formula:C20H17FO2SColor and Shape:Yellow PowderMolecular weight:340.09333Sulindac Sulfide-d6 (Major)
CAS:Controlled ProductFormula:C20D6H11FO2SColor and Shape:NeatMolecular weight:346.448Sulindac Sulfide
CAS:Stability Hygroscopic Applications An active metabolite of Sulindac. Inhibits cyclooxygenase, but induces apoptosis by a cyclooxygenase-independent mechanism. Inhibition of Ras activation of Ref-1. Impairs nucleotide exchange on Ras by CDC25 and accelerates Ras hydrolysis of GTP by p120GAP. References Hermann, C., et al.: Oncogene, 17, 1769 (1998), Lim, T.J., et al.: Biochem. Pharmacol., 58, 1097 (1999), Zhang, Z. and DuBois, R.N.: Gastroenterology, 118, 1012 (2000),Formula:C20H17FO2SColor and Shape:Yellow-OrangeMolecular weight:340.41Sulindac sulfide
CAS:Sulindac sulfide: NSAID targeting COX-1, inhibits Ras-Raf-1 and gamma-secretase (IC50: 20.2 μM), active sulinic acid metabolite.Formula:C20H17FO2SPurity:99.68%Color and Shape:SolidMolecular weight:340.41
